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The influence of glacial-isostatic adjustment (GIA) on the motion of tectonic plates is usually neglected. Employing a recently developed numerical approach, we examine the effect of glacial loading on the motion of the Earth’s tectonic plates where we consider an elastic lithosphere of laterally variable strength and the plates losely connected by low viscous zones. The aim of this paper is to elucidate the physical processes which control the GIA-induced horizontal motion and to assess the impact of finite plate-boundary zones. We show that the present-day motion of tectonic plates induced by GIA is at, or above, the order of accuracy of the plate motions determined by very precise GPS observations. Therefore, its contribution should be considered when interpreting the mechanism controlling plate motion.